Serveur d'exploration sur la grippe en France

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Intensive care unit surveillance of influenza infection in France: the 2009/10 pandemic and the three subsequent seasons.

Identifieur interne : 000193 ( Main/Exploration ); précédent : 000192; suivant : 000194

Intensive care unit surveillance of influenza infection in France: the 2009/10 pandemic and the three subsequent seasons.

Auteurs : Isabelle Bonmarin [France] ; Emmanuel Belchior ; Jean Bergounioux ; Christian Brun-Buisson ; Bruno Mégarbane ; Jean Loup Chappert ; Bruno Hubert ; Yann Le Strat ; Daniel Lévy-Bruhl

Source :

RBID : pubmed:26607262

Descripteurs français

English descriptors

Abstract

During the 2009/10 pandemic, a national surveillance system for severe influenza cases was set up in France. We present results from the system's first four years. All severe influenza cases admitted to intensive care units (ICU) were reported to the Institut de Veille Sanitaire using a standardised form: data on demographics, immunisation and virological status, risk factors, severity (e.g. acute respiratory distress syndrome (ARDS) onset, mechanical ventilation, extracorporeal life support) and outcome. Multivariate analysis was performed to identify factors associated with ARDS and death. The number of confirmed influenza cases varied from 1,210 in 2009/10 to 321 in 2011/12. Most ICU patients were infected with A(H1N1)pdm09, except during the 2011/12 winter season when A(H3N2)-related infections predominated. Patients' characteristics varied according to the predominant strain. Based on multivariate analysis, risk factors associated with death were age ≥ 65 years, patients with any of the usual recommended indications for vaccination and clinical severity. ARDS occurred more frequently in patients who were middle-aged (36-55 years), pregnant, obese, or infected with A(H1N1)pdm09. Female sex and influenza vaccination were protective. These data confirm the persistent virulence of A(H1N1)pdm09 after the pandemic and the heterogeneity of influenza seasons, and reinforce the need for surveillance of severe influenza cases.

DOI: 10.2807/1560-7917.ES.2015.20.46.30066
PubMed: 26607262


Affiliations:


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Le document en format XML

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<div type="abstract" xml:lang="en">During the 2009/10 pandemic, a national surveillance system for severe influenza cases was set up in France. We present results from the system's first four years. All severe influenza cases admitted to intensive care units (ICU) were reported to the Institut de Veille Sanitaire using a standardised form: data on demographics, immunisation and virological status, risk factors, severity (e.g. acute respiratory distress syndrome (ARDS) onset, mechanical ventilation, extracorporeal life support) and outcome. Multivariate analysis was performed to identify factors associated with ARDS and death. The number of confirmed influenza cases varied from 1,210 in 2009/10 to 321 in 2011/12. Most ICU patients were infected with A(H1N1)pdm09, except during the 2011/12 winter season when A(H3N2)-related infections predominated. Patients' characteristics varied according to the predominant strain. Based on multivariate analysis, risk factors associated with death were age ≥ 65 years, patients with any of the usual recommended indications for vaccination and clinical severity. ARDS occurred more frequently in patients who were middle-aged (36-55 years), pregnant, obese, or infected with A(H1N1)pdm09. Female sex and influenza vaccination were protective. These data confirm the persistent virulence of A(H1N1)pdm09 after the pandemic and the heterogeneity of influenza seasons, and reinforce the need for surveillance of severe influenza cases. </div>
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<Year>2015</Year>
<Month>11</Month>
<Day>27</Day>
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<PubMedPubDate PubStatus="pubmed">
<Year>2015</Year>
<Month>11</Month>
<Day>27</Day>
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<PubMedPubDate PubStatus="medline">
<Year>2016</Year>
<Month>4</Month>
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<Hour>6</Hour>
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<PublicationStatus>ppublish</PublicationStatus>
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<ArticleId IdType="pubmed">26607262</ArticleId>
<ArticleId IdType="doi">10.2807/1560-7917.ES.2015.20.46.30066</ArticleId>
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<country>
<li>France</li>
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<name sortKey="Belchior, Emmanuel" sort="Belchior, Emmanuel" uniqKey="Belchior E" first="Emmanuel" last="Belchior">Emmanuel Belchior</name>
<name sortKey="Bergounioux, Jean" sort="Bergounioux, Jean" uniqKey="Bergounioux J" first="Jean" last="Bergounioux">Jean Bergounioux</name>
<name sortKey="Brun Buisson, Christian" sort="Brun Buisson, Christian" uniqKey="Brun Buisson C" first="Christian" last="Brun-Buisson">Christian Brun-Buisson</name>
<name sortKey="Chappert, Jean Loup" sort="Chappert, Jean Loup" uniqKey="Chappert J" first="Jean Loup" last="Chappert">Jean Loup Chappert</name>
<name sortKey="Hubert, Bruno" sort="Hubert, Bruno" uniqKey="Hubert B" first="Bruno" last="Hubert">Bruno Hubert</name>
<name sortKey="Le Strat, Yann" sort="Le Strat, Yann" uniqKey="Le Strat Y" first="Yann" last="Le Strat">Yann Le Strat</name>
<name sortKey="Levy Bruhl, Daniel" sort="Levy Bruhl, Daniel" uniqKey="Levy Bruhl D" first="Daniel" last="Lévy-Bruhl">Daniel Lévy-Bruhl</name>
<name sortKey="Megarbane, Bruno" sort="Megarbane, Bruno" uniqKey="Megarbane B" first="Bruno" last="Mégarbane">Bruno Mégarbane</name>
</noCountry>
<country name="France">
<noRegion>
<name sortKey="Bonmarin, Isabelle" sort="Bonmarin, Isabelle" uniqKey="Bonmarin I" first="Isabelle" last="Bonmarin">Isabelle Bonmarin</name>
</noRegion>
</country>
</tree>
</affiliations>
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